Structural variation and complex regions
Where short-read information is insufficient for complex rearrangements, repeat regions or haplotype relationships, assess the complementary value of a long-read strategy.
For complex research questions
Connect deeper molecular analysis capabilities
Polyseq Biotech provides a long-read nanopore sequencing platform and related technologies. NovoBay helps assess application directions, connect technical resources and coordinate projects around research, clinical research and drug development needs.
LONG-READ NANOPORE
Preserve richer molecular information across long reads
Nanopore sequencing can provide dimensions of information for complex structures, methylation and transcripts that differ from short-read approaches. Fit should be assessed against the sample, study design, data-analysis capability and intended outcome.
- Read lengthLong reads may support research into complex genomic regions, structural variation and full-length transcripts.
- Multidimensional informationApplicable workflows may explore sequence, structure and methylation information.
- Native moleculesDirect DNA and RNA pathways may reduce bias introduced by some conversion and amplification steps.
- Performance conditionsPartner materials cite metrics including Q20+; actual performance depends on sample, library preparation, equipment and analysis workflow.
POTENTIAL RESEARCH DIRECTIONSLet the research question define
Let the research question define
the sequencing and analysis strategy
These directions help professional partners identify potential value; they do not guarantee a result for any particular project or clinical use.
Methylation and epigenetic information
Explore native molecular signals according to the study design, adding an information layer for disease-mechanism or biomarker research.
Full-length transcripts and native RNA
Assess direct RNA or long-read transcriptome pathways for splice isoforms, fusion transcripts and expression studies.
HOW WE COLLABORATE
How NovoBay participates
We organize collaboration around need, resources and execution. Polyseq Biotech and the relevant professional teams confirm experimental design, performance assessments and technical support.
Define the question
Clarify disease focus, research question, sample type and the information sought.
Assess the technology
Coordinate partner assessment of platform capability, workflow conditions and evidence fit.
Design the project
Define samples, scope, analytical path, resources and responsibility boundaries.
Coordinate implementation
Coordinate execution, milestone communication and later translation discussions under the collaboration arrangements.
This page is primarily for research and professional collaboration assessment. Platform use, performance and regulatory status are subject to Polyseq Biotech's formal materials and applicable requirements.
Discuss a long-read sequencing question
Share the sample type, research objective and main limitations of the current approach.